How Earth’s oddest mammal got to be so bizarre

It lays eggs, but nurses, it is toothless, has a venomous spur, has webbed feet, fur that glows and has 10 sex chromosomes. Ever since Europeans discovered the platypus in Australia during the late 1700’s, the quirky, duck-billed, semiaquatic creature has baffled scientific researchers.

Modern day researchers are still trying to understand how the platypus — often considered to be the world's oddest mammal — got to be so unique. Their understandings have now advanced, to a great degree. For the first time, an international team of researchers, led by University of Copenhagen biologists, has mapped a complete platypus genome. The study has been published in the scientific journal, Nature.

"The complete genome has provided us with the answers to how a few of the platypus’ bizarre features emerged. At the same time, decoding the genome for platypus is important for improving our understanding of how other mammals evolved — including us humans. It holds the key as to why we and other eutheria mammals evolved to become animals that give birth to live young instead of egg-laying animals," explains Professor Guojie Zhang of the Department of Biology.

The platypus belongs to an ancient group of mammals — monotremes — which existed millions of years prior to the emergence of any modern-day mammal.

"Indeed, the platypus belongs to the Mammalia class. But genetically, it is a mixture of mammals, birds and reptiles. It has preserved many of its ancestors’ original features — which probably contribute to its success in adapting to the environment they live in," says Professor Zhang.

Lays eggs, sweats milk and has no teeth              

One of the platypus' most unusual characteristics is that, while it lays eggs, it also has mammary glands used to feed its babies, not through nipples, but by milk — which is sweat from its body.

During our own evolution, we humans lost all three so-called vitellogenin genes, each of which is important for the production of egg yolks. Chickens on the other hand, continue to have all three. The study demonstrates that platypuses still carry one of these three vitellogenin genes, despite having lost the other two roughly 130 million years ago. The platypus continues to lay eggs by virtue of this one remaining gene. This is probably because it is not as dependent on creating yolk proteins as birds and reptiles are, as platypuses produce milk for their young.

In all other mammals, vitellogenin genes have been replaced with casein genes, which are responsible for our ability to produce casein protein, a major component in mammalian milk. The new research demonstrates that the platypus carries casein genes as well, and that the composition of their milk is thereby quite similar to that of cows, humans and other mammals.

"It informs us that milk production in all extant mammal species has been developed through the same set of genes derived from a common ancestor which lived more than 170 million years ago — alongside the early dinosaurs in the Jurassic period," says Guojie Zhang.

Another trait that makes the platypus so unique is that, unlike the vast majority of mammals, it is toothless. Although this monotremes’ nearest ancestors were toothed, the modern platypus is equipped with two horn plates that are used to mash food. The study reveals that the platypus lost its teeth roughly 120 million years ago, when four of the eight genes responsible for tooth development disappeared.

Only animal with 10 sex chromosomes

Yet another platypus oddity investigated by the researchers was how their sex is determined. Both humans and every other mammal on Earth have two sex chromosomes that determine sex – the X and Y chromosome system in which XX is female and XY is male. The monotremes, however, including our duck-billed friends from Down Under, have 10 sex chromosomes, with five Y and five X chromosomes.

Thanks to the near-complete chromosomal level genomes, researchers can now suggest that these 10 sex chromosomes in the ancestors of the monotremes were organized in a ring form which was later broken away into many small pieces of X and Y chromosomes. At the same time, the genome mapping reveals that the majority of monotreme sex chromosomes have more in common with chickens than with humans. But what it shows, is an evolutionary link between mammals and birds.

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