Illuminating novel molecular mechanisms of human skeletal muscle insulin sensitivity using personalised phosphoproteomics

PhD defence by Magnus Romme Leandersson

Assessment Committee

Assoc. Professor Lasse Gliemann, NEXS, University of Copenhagen (Chairperson)
Professor Anna Krook, Karolinska, Stockholm
Professor Hadi Al-Hasani, German Diabetes Center, Düsseldorf

Supervisors

Professor Jørgen Frank Pind Wojtaszewski
Associate Professor Rasmus Kjøbsted

Department

Department of Nutrition, Exercise and Sports

Place

Building: HCØ, Room: Aud 6, Universitetsparken 5, 2100 Copenhagen

Email address to gain access to the thesis: ljp559@alumni.ku.dk.
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Short description of the thesis

Exercise enhances the effects of the hormone insulin in skeletal muscle, making it a cornerstone for preventing and managing insulin resistance (prediabetes) and Type 2 diabetes. However, because regular exercise is not always feasible or sustained, developing pharmacological therapies that replicate these metabolic benefits has become a major clinical goal. Designing such treatments requires identification of the responsible molecular mechanisms. This thesis applies a state-of-the-art approach termed "personalised phosphoproteomics" to study these mechanisms in human skeletal muscle. The findings uncover key targets that could help transform beneficial exercise effects into a pill.